AutoHotKey is a free open source tools to customize your keyboard, joystic, and mouse (it is also compatible with AutoIt v2. AutoHotkey includes a quick tutorial and automatic script writer (macro recording) that will records your keystrokes, mouse clicks, and a comprehensive help file.
Besides the automation features that AutoHotKey offers, it is able to excels at hotkeys, able to make any combination of all keyboard key, joystick and mouse button into hotkey. It is also able to override windows shortcut keys function such as Win + E and Win + R . It may also help alleviate RSI; for example, it can create substitutes for Alt-Tab using keys, mouse wheel, or buttons.

Major Automation Features:
* Define abbreviations that expand as you type them (auto-replace).
* Create custom GUI windows and menu bars.
* Retrieve or change the volume, mute, and other settings of any soundcard.
* Remap keys and mouse/joystick buttons.
* Send keystrokes and mouse clicks to any window (without needing to activate it).
* Launch programs, shortcuts, URLs, and documents.
* Activate, hide, close, or resize any window.
* Make a window transparent and/or always-on-top.
* Change the priority of a process or close it.
* Create custom tray icon menus and popup menus.
* Use a joystick as a mouse.
* Monitor your system (e.g. close unwanted windows the moment they appear).
* Automate game actions by detecting pixel colors.
* Retrieve and change the clipboard´s contents, even if it contains files copied from the Explorer.
* Perform any operation upon a set of files and folders that match a wildcard pattern.
* Read, write, and parse text files more easily than in most other languages.
* Work with the registry and INI files using the included interface commands.
* Display simple tooltips and balloon tips.
* Display dialog boxes to interact with the user.
* Convert any script into an EXE that can be run on any computer.